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#tregs

10 posts3 participants0 posts today
David Usharauli<p>Initially, the thymus was believed to be an endocrine organ because its removal in early life caused changes in the ovaries and testes. Now, we understand these changes were linked to autoimmunity. 🤔🔬💡 </p><p><a href="https://bookstodon.com/tags/thymus" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>thymus</span></a> <br><a href="https://bookstodon.com/tags/Tregs" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Tregs</span></a><br><a href="https://bookstodon.com/tags/endocrine" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>endocrine</span></a> <br><a href="https://bookstodon.com/tags/autoimmunity" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>autoimmunity</span></a> <br><a href="https://bookstodon.com/tags/science" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>science</span></a><br><a href="https://bookstodon.com/tags/history" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>history</span></a></p>
David Usharauli<p>6/ 🔬 These inconsistencies raise key questions about how Treg suppression works in different contexts. More research needed! 🏗️📖</p><p>What do you think? Drop your thoughts below! ⬇️💬 </p><p><a href="https://bookstodon.com/tags/immunology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>immunology</span></a><br><a href="https://bookstodon.com/tags/Tregs" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Tregs</span></a><br><a href="https://bookstodon.com/tags/Foxp3" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Foxp3</span></a><br><a href="https://bookstodon.com/tags/science" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>science</span></a></p>
David Usharauli<p>1/ 📢 A new study was recently published in Science Translational Medicine investigating antigen specificity in Treg-mediated suppression of effector T cells in a celiac model. 🔬🍞 </p><p><a href="https://bookstodon.com/tags/Foxp3" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Foxp3</span></a><br><a href="https://bookstodon.com/tags/Tregs" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Tregs</span></a><br><a href="https://bookstodon.com/tags/celiac" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>celiac</span></a><br><a href="https://bookstodon.com/tags/immunology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>immunology</span></a><br><a href="https://bookstodon.com/tags/science" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>science</span></a></p><p><a href="https://www.science.org/doi/10.1126/scitranslmed.adr8941" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">science.org/doi/10.1126/scitra</span><span class="invisible">nslmed.adr8941</span></a></p>
David Usharauli<p>6/ How can antigen-specific Tregs lose their functionality? By losing the antigen. Without the anchor antigen to engage the Treg TCR and collaborate with other T cells for IL-2, the process breaks down. 🔓 </p><p><a href="https://bookstodon.com/tags/Tregs" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Tregs</span></a> <br><a href="https://bookstodon.com/tags/AntigenSpecific" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>AntigenSpecific</span></a></p>
David Usharauli<p>9/ If the lost anchor antigen is similar to the target self-antigen, Treg–IL-2+ T cell collaboration stays intact. 🔄 If they’re different, losing the anchor antigen shouldn’t affect other self-antigens. ⚖️ No disruption → No autoimmunity! </p><p><a href="https://bookstodon.com/tags/Tregs" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Tregs</span></a> <br><a href="https://bookstodon.com/tags/Autoimmunity" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Autoimmunity</span></a></p>
David Usharauli<p>7/ But how could we lose a self-antigen? Not realistic. And if a self-antigen is lost, how can autoimmunity occur? No antigen, no autoimmunity. 🚫 </p><p><a href="https://bookstodon.com/tags/SelfAntigen" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>SelfAntigen</span></a> <br><a href="https://bookstodon.com/tags/Tregs" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Tregs</span></a> <br><a href="https://bookstodon.com/tags/Autoimmunity" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Autoimmunity</span></a></p>
David Usharauli<p>4/ Based on this evidence, if Tregs inhibit other T cells in an antigen-specific manner, they must recognize similar antigens. Likewise, IL-2 supply from other T cells is also likely antigen-specific. 🔑</p><p><a href="https://bookstodon.com/tags/Tregs" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Tregs</span></a> <br><a href="https://bookstodon.com/tags/IL2" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>IL2</span></a> <br><a href="https://bookstodon.com/tags/TCellReceptors" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>TCellReceptors</span></a></p>
David Usharauli<p>5/ But what antigens do Tregs and other T cells recognize to collaborate on IL-2 supply? Is it auto-antigen? Unlikely. Why? Because for autoimmunity to happen, Tregs would need to lose their functionality. ⚠️ </p><p><a href="https://bookstodon.com/tags/Autoimmunity" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Autoimmunity</span></a> <br><a href="https://bookstodon.com/tags/Tregs" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Tregs</span></a></p>
David Usharauli<p>1/ 🧵 What is the TCR specificity of Foxp3+ Tregs? They're as diverse as conventional T cells, but very few antigen-specific Tregs have been described. This lack of specificity leads to many unfounded statements. Let's dive in. 🔬 </p><p><a href="https://bookstodon.com/tags/science" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>science</span></a><br><a href="https://bookstodon.com/tags/Immunology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Immunology</span></a> <br><a href="https://bookstodon.com/tags/Foxp3" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Foxp3</span></a><br><a href="https://bookstodon.com/tags/Tregs" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Tregs</span></a></p>
David Usharauli<p>2/ A common claim: Tregs are autoreactive, meaning they recognize self-antigens. Since Tregs protect against autoimmunity, this seems logical. But does it really hold up? 🤔 Let's run a thought experiment. 💭 </p><p><a href="https://bookstodon.com/tags/Tregs" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Tregs</span></a> <br><a href="https://bookstodon.com/tags/SelfAntigen" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>SelfAntigen</span></a></p>
Scientific Frontline<p>Scientists at Harvard Medical School have discovered a distinct population of <a href="https://mastodon.social/tags/Tregs" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Tregs</span></a> dwelling in the protective layers of the <a href="https://mastodon.social/tags/brains" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>brains</span></a> of healthy mice with a repertoire much broader than inflammation control.<br><a href="https://mastodon.social/tags/Biology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Biology</span></a> <a href="https://mastodon.social/tags/Biomedical" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Biomedical</span></a> <a href="https://mastodon.social/tags/Neuroscience" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Neuroscience</span></a> <a href="https://mastodon.social/tags/sflorg" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>sflorg</span></a><br><a href="https://www.sflorg.com/2025/01/bio01282501.html" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">sflorg.com/2025/01/bio01282501</span><span class="invisible">.html</span></a></p>
David Usharauli<p>1/ Let's do a deep dive into the best research article on Foxp3+ Tregs this month (January 2025) and highlight its strengths and weaknesses. </p><p><a href="https://bookstodon.com/tags/immunology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>immunology</span></a><br><a href="https://bookstodon.com/tags/Tregs" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Tregs</span></a><br><a href="https://bookstodon.com/tags/allergy" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>allergy</span></a><br><a href="https://bookstodon.com/tags/microbiota" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>microbiota</span></a><br><a href="https://bookstodon.com/tags/microbiome" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>microbiome</span></a><br><a href="https://bookstodon.com/tags/Foxp3" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#<span>Foxp3</span></a> </p><p><a href="https://www.nature.com/articles/s41586-024-08440-7" rel="nofollow noopener noreferrer" translate="no" target="_blank"><span class="invisible">https://www.</span><span class="ellipsis">nature.com/articles/s41586-024</span><span class="invisible">-08440-7</span></a></p>
Chuck Darwin<p>“It’s difficult to think of a disease, injury or injection that doesn’t involve some kind of <a href="https://c.im/tags/immune" class="mention hashtag" rel="tag">#<span>immune</span></a> <a href="https://c.im/tags/response" class="mention hashtag" rel="tag">#<span>response</span></a>, <br />and our finding really changes the way we could control this response,” said Professor Adrian Liston from the University’s Department of Pathology and the study’s corresponding author. </p><p>“We’ve uncovered new rules of the immune system. <br />This ‘unified healer army’ can do everything<br /> – repair injured muscle, make your fat cells respond better to insulin, regrow hair follicles. </p><p>To think that we could use it in such an enormous range of diseases is fantastic: <br />it’s got the potential to be used for almost everything.”</p><p>Lymphoid organs are integral parts of the immune system, responsible for producing <a href="https://c.im/tags/lymphocytes" class="mention hashtag" rel="tag">#<span>lymphocytes</span></a>, a type of white blood cell that includes T cells. </p><p>T cells begin life in the bone marrow and then move to the thymus, an organ in the upper mid-chest, <br />where they mature into specialized subsets, including <a href="https://c.im/tags/Tregs" class="mention hashtag" rel="tag">#<span>Tregs</span></a>. </p><p>Once fully matured, T cells are exported to peripheral lymphatic tissues and organs like the spleen, tonsils, and lymph nodes<br /> (some move to the bloodstream). </p><p>It was thought that’s where Tregs stayed, on ‘standby’ until called upon by the immune system.</p><p>To test this, the researchers analyzed the Tregs present in 48 different tissues in mice, including lymphoid and non-lymphoid tissues and tissues associated with the gut. </p><p>They found them in all tissue types, suggesting that Tregs weren’t specialized cell populations confined to lymphoid tissues but moved around the body, executing repair functions in areas that need it.</p><p>“Now that we know these regulatory T cells are present everywhere in the body, in principle ⭐️we can start to make immune suppression and tissue regeneration treatments that are targeted against a single organ⭐️<br /> – a vast improvement on current treatments that are like hitting the body with a sledgehammer,” Liston said<br /><a href="https://newatlas.com/medical/regulatory-t-cells-discovery/" target="_blank" rel="nofollow noopener noreferrer" translate="no"><span class="invisible">https://</span><span class="ellipsis">newatlas.com/medical/regulator</span><span class="invisible">y-t-cells-discovery/</span></a></p>
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